The World Health Organization (WHO)has released the first-ever Clinical Treatment Guidelines for Tobacco Cessation in Adults. The WHO recommends a comprehensive set of tobacco cessation interventions, including behavioral support delivered by health-care providers, digital cessation interventions and pharmacological treatments in a first guideline on tobacco cessation. The guideline focuses on helping the more than 750 million tobacco users who want to quit all forms of tobacco. The recommendations are relevant for all adults seeking to quit various tobacco products, including cigarettes, waterpipes, smokeless tobacco products, cigars, roll-your-own tobacco, and heated tobacco products (HTPs). “This guideline marks a crucial milestone in our global battle against these dangerous products," said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. "It empowers countries with the essential tools to effectively support individuals in quitting tobacco and alleviate the global burden of tobacco-related diseases.” Over 60% of the world's 1.25 billion tobacco users – more than 750 million people – wish to quit, yet 70% lack access to effective cessation services. This gap exists due to challenges faced by health systems, including resource limitations. “The immense struggle that people face when trying to quit smoking cannot be overstated. We need to deeply appreciate the strength it takes and the suffering endured by individuals and their loved ones to overcome this addiction,” said Dr Rüdiger Krech, Director of Health Promotion at WHO. ”These guidelines are designed to help communities and governments provide the best possible support and assistance for those on this challenging journey.”