This article examines how corporations that produce and market health-harming products such as tobacco, ultra-processed foods, alcohol, and certain chemicals play a significant role in driving the global rise in chronic disease. The authors describe how these industries shape consumer behavior, influence policy, and contribute to health inequities, particularly among vulnerable populations. The concept of “commercial determinants of health” is introduced, emphasizing the need to look beyond individual behaviors to broader systemic drivers. It also highlights how current regulatory approaches often fall short in addressing the scale of corporate influence. Stronger, more coordinated policy actions, including regulation, transparency, and accountability measures, are needed to better protect public health.